Dupixent is a drug used to treat severe atopic dermatitis. It also helps prevent eczema flare-ups. It is a combination of two medications, dupilumab and emollient cream. The main side effect is a high risk for infection. It can be useful in adult patients who have moderate to severe atopic dermatitis. The drug also should not be used in patients who have had an allergy or hypersensitivity reaction to dupilumab, or those with unstable medical conditions. In adults, the drug is taken once a month by injection through the skin. In children, it is given as an inhaled treatment using a nebulizer.
The drug is a monoclonal antibody. It binds to and inhibits the effects of interleukin-4, a molecule that signals the immune system to cause inflammation. This then reduces the symptoms of atopic dermatitis. For it to be effective, it must be used regularly as prescribed by the doctor. It also should not be used with other medications or treatments for atopic dermatitis without first discussing this with your doctor. Also, do not stop taking it suddenly as this may cause an allergic reaction known as systemic corticosteroid withdrawal syndrome, which can result in nausea, vomiting, fatigue and weight loss.
In addition, it can cause infections and a rise in liver enzymes. When the drug is used in patients with moderate to severe atopic dermatitis, the chance of the skin condition returning after it is stopped is reduced. This is known as its long-term control benefit. Therefore, it can be used as maintenance treatment given monthly, quarterly or annually. The drug is contraindicated in patients who have a serious infection such as tuberculosis, or an active infection with herpes, chickenpox or measles. Also, it is not recommended for use in patients who have severe asthma attacks and require regular use of inhaled corticosteroids due to the risk of systemic corticosteroid withdrawal syndrome after stopping the drug.
You can also read more on Addiction recovery